Labeling on parenteral nutrient admixtures

Chemical incompatibility of parenteral drug admixtures.

Compatibility and stability of additives in parenteral nutrition admixtures.

The addition of additives (electrolytes, trace elements, and vitamins) to parenteral nutrition (PN) mixtures can lead to precipitation as a result of physical incompatibilities and can lead to chemical degradation of individual ingredients. The most significant cause of precipitation is excessive concentrations of calcium phosphate. The most significant cause of chemical instability is the oxid...

Calculating aluminum content in total parenteral nutrition admixtures.

MARYBETH DRISCOLL, B.S.PHARM., is Staff Pharmacist, Parenteral Admixture Compounding Facility, Department of Pharmacy, B. I. Deaconess Medical Center (BIDMC), Boston, MA. DAVID F. DRISCOLL, PH.D., is Assistant Professor of Medicine, Harvard Medical School, and Senior Researcher, Nutrition/Infection Laboratory, Department of Medicine, BIDMC. Calculating aluminum content in total parenteral nutri...

Practical handling of AIO admixtures – Guidelines on Parenteral Nutrition, Chapter 10

All-in-one admixtures (AIO-admixtures) provide safe, effective and low-risk PN (parenteral nutrition) for practically all indications and applications. Water, energy (carbohydrates and lipids), amino acids, vitamins and trace elements are infused together with PN either as industrially-manufactured AIO admixtures provided as two- or three-chamber bags (shelf life usually more than 12 months) co...

Effect of Storage Temperature on the Stability of Total Parenteral Nutrition Admixtures Prepared for Infants.

Physical, chemical and microbiological stability of total parenteral nutrient (TPN) admixtures was studied as a function of storage time and temperature. Particle size analysis and zeta potential measurements were carried out to evaluate the possible changes in the kinetic stability of the emulsions as a function of storage time and temperature. The concentration changes of the applied additive...